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Parkinson’s disease: Without appendicitis, you will get less

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A removal of the cecum may reduce the risk for Parkinson’s disease. This suggests an international study under the direction of Bryan A. Killinger from the Van Andel Research Institute in Grand Rapids (USA).

in the journal “Science Translational Medicine” published a work based on the disease data from a total of 1.6 million people. And you are the first to provide information on a possible influence of the cecum to the pathogenesis of Parkinson’s disease.

scientists have observed that a distant appendage to reduce the risk for later Parkinson’s diagnosis by about 20 percent. In the case of people living on the Land, were there even 25 percent. How can that be?

Parkinson’s disease is usually diagnosed on the basis of motor symptoms. It is also known that certain intestinal complaints harbingers of Parkinson’s disease can be. You can already occur years before the first motor failures.

There is the theory that Parkinson’s disease through an accumulation of Alpha-Synuclein proteins in the brain region Substantia nigra is caused. In previous studies, researchers at the Parkinson’s had found patients aggregated Alpha-Synuclein in nerve cells of the gastro-intestinal tract.

In the current study, the researchers searched for Alpha-Synuclein in the distant Worm-like appendages. And you were able to find, even in otherwise healthy people. As a conclusion of these investigations, the researchers say that the “normal human cecum contains pathogenic forms of Alpha-Synuclein and the risk of Parkinson’s disease-affected diagnosis.” Such a connection fits well to the static data.

“The Killinger and his colleagues have presented an epidemiological-molecular study is competently crafted and methodically versatile,” says Professor Heiko Braak of the working group’s clinical neuro-anatomy at the University hospital in Ulm.

“The main focus of the study is the Appendix that contains the Findings of the authors already in the youth age large amounts of the normal and the diverse modified Alpha-Synuclein, which could in the end be found in the Form of germs on the way into Branches of the Nervus vagus,” says Braak. From there, you could then be taken up in the brain and Parkinson’s trigger.

“The results of this study are consistent with previous Reports,” Francisco Pan-Montojo by the centre for neuropathology and Prion at the hospital of the University of Munich.

“The current findings are nevertheless surprising because they suggest that up to 25 percent of Parkinson’s diagnoses says on the could presence of condensed and aggregated forms of Alpha-Synuclein-proteins on the worm, set to be due”, in Pan-Montojo.

Walter Schulz-Schaeffer, Director of the Institute for neuropathology at the University hospital of the Saarland, holds the current study is also particularly interesting because of the “influence of the consumption of plant protection products on the stomach-intestine-discussed tract on the formation of a Parkinson’s disease”.

However, Schulz-Schaeffer warns against drawing hasty conclusions: “the study justifies an appendectomy to prevent Parkinson’s disease.” The statistical connection was much too low.